Direct Binding of Retromer to Human Papillomavirus Type 16 Minor Capsid Protein L2 Mediates Endosome Exit during Viral Infection
Identifieur interne : 000054 ( Main/Exploration ); précédent : 000053; suivant : 000055Direct Binding of Retromer to Human Papillomavirus Type 16 Minor Capsid Protein L2 Mediates Endosome Exit during Viral Infection
Auteurs : Andreea Popa [États-Unis] ; Wei Zhang [États-Unis] ; Megan S. Harrison [États-Unis] ; Kylia Goodner [États-Unis] ; Teymur Kazakov [États-Unis] ; Edward C. Goodwin [États-Unis] ; Alex Lipovsky [États-Unis] ; Christopher G. Burd [États-Unis] ; Daniel Dimaio [États-Unis]Source :
- PLoS Pathogens [ 1553-7366 ] ; 2015.
Abstract
Trafficking of human papillomaviruses to the Golgi apparatus during virus entry requires retromer, an endosomal coat protein complex that mediates the vesicular transport of cellular transmembrane proteins from the endosome to the Golgi apparatus or the plasma membrane. Here we show that the HPV16 L2 minor capsid protein is a retromer cargo, even though L2 is not a transmembrane protein. We show that direct binding of retromer to a conserved sequence in the carboxy-terminus of L2 is required for exit of L2 from the early endosome and delivery to the
Url:
DOI: 10.1371/journal.ppat.1004699
PubMed: 25693203
PubMed Central: 4334968
Affiliations:
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Burd</name><affiliation wicri:level="2"><nlm:aff id="aff002"><addr-line>Department of Cell Biology, Yale School of Medicine, New Haven, Connecticut, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Biology, Yale School of Medicine, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author><author><name sortKey="Dimaio, Daniel" sort="Dimaio, Daniel" uniqKey="Dimaio D" first="Daniel" last="Dimaio">Daniel Dimaio</name><affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>Department of Genetics, Yale School of Medicine, New Haven, Connecticut, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Yale School of Medicine, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff003"><addr-line>Department of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff004"><addr-line>Department of Molecular Biophysics & Biochemistry, Yale School of Medicine, New Haven, Connecticut, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Biophysics & Biochemistry, Yale School of Medicine, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff005"><addr-line>Yale Cancer Center, New Haven, Connecticut, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Yale Cancer Center, New Haven, Connecticut</wicri:regionArea><placeName><region type="state">Connecticut</region></placeName></affiliation></author></analytic><series><title level="j">PLoS Pathogens</title><idno type="ISSN">1553-7366</idno><idno type="eISSN">1553-7374</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Trafficking of human papillomaviruses to the Golgi apparatus during virus entry requires retromer, an endosomal coat protein complex that mediates the vesicular transport of cellular transmembrane proteins from the endosome to the Golgi apparatus or the plasma membrane. Here we show that the HPV16 L2 minor capsid protein is a retromer cargo, even though L2 is not a transmembrane protein. We show that direct binding of retromer to a conserved sequence in the carboxy-terminus of L2 is required for exit of L2 from the early endosome and delivery to the <italic>trans</italic>-Golgi network during virus entry. This binding site is different from known retromer binding motifs and can be replaced by a sorting signal from a cellular retromer cargo. Thus, HPV16 is an unconventional particulate retromer cargo, and retromer binding initiates retrograde transport of viral components from the endosome to the <italic>trans</italic>-Golgi network during virus entry. We propose that the carboxy-terminal segment of L2 protein protrudes through the endosomal membrane and is accessed by retromer in the cytoplasm.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Parkin, Dm" uniqKey="Parkin D">DM Parkin</name></author><author><name sortKey="Bray, F" uniqKey="Bray F">F Bray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Wj" uniqKey="Liu W">WJ Liu</name></author><author><name sortKey="Gissmann, L" uniqKey="Gissmann L">L Gissmann</name></author><author><name sortKey="Sun, Xy" uniqKey="Sun X">XY Sun</name></author><author><name sortKey="Kanjanahaluethai, A" uniqKey="Kanjanahaluethai A">A Kanjanahaluethai</name></author><author><name sortKey="Muller, M" uniqKey="Muller M">M Muller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Jw" uniqKey="Wang J">JW Wang</name></author><author><name sortKey="Roden, Rb" uniqKey="Roden 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Iwasaki</name></author><author><name sortKey="Dimaio, D" uniqKey="Dimaio D">D DiMaio</name></author><author><name sortKey="Tang, Bl" uniqKey="Tang B">BL Tang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Connecticut</li></region></list><tree><country name="États-Unis"><region name="Connecticut"><name sortKey="Popa, Andreea" sort="Popa, Andreea" uniqKey="Popa A" first="Andreea" last="Popa">Andreea Popa</name></region><name sortKey="Burd, Christopher G" sort="Burd, Christopher G" uniqKey="Burd C" first="Christopher G." last="Burd">Christopher G. Burd</name><name sortKey="Dimaio, Daniel" sort="Dimaio, Daniel" uniqKey="Dimaio D" first="Daniel" last="Dimaio">Daniel Dimaio</name><name sortKey="Dimaio, Daniel" sort="Dimaio, Daniel" uniqKey="Dimaio D" first="Daniel" last="Dimaio">Daniel Dimaio</name><name sortKey="Dimaio, Daniel" sort="Dimaio, Daniel" uniqKey="Dimaio D" first="Daniel" last="Dimaio">Daniel Dimaio</name><name sortKey="Dimaio, Daniel" sort="Dimaio, Daniel" uniqKey="Dimaio D" first="Daniel" last="Dimaio">Daniel Dimaio</name><name sortKey="Goodner, Kylia" sort="Goodner, Kylia" uniqKey="Goodner K" first="Kylia" last="Goodner">Kylia Goodner</name><name sortKey="Goodwin, Edward C" sort="Goodwin, Edward C" uniqKey="Goodwin E" first="Edward C." last="Goodwin">Edward C. Goodwin</name><name sortKey="Harrison, Megan S" sort="Harrison, Megan S" uniqKey="Harrison M" first="Megan S." last="Harrison">Megan S. Harrison</name><name sortKey="Kazakov, Teymur" sort="Kazakov, Teymur" uniqKey="Kazakov T" first="Teymur" last="Kazakov">Teymur Kazakov</name><name sortKey="Lipovsky, Alex" sort="Lipovsky, Alex" uniqKey="Lipovsky A" first="Alex" last="Lipovsky">Alex Lipovsky</name><name sortKey="Zhang, Wei" sort="Zhang, Wei" uniqKey="Zhang W" first="Wei" last="Zhang">Wei Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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